An outstanding article on ketamine

November 1, 2013 in Research

Here is an outstanding essay explaining ketamine treatment for depression: The current mental health crisis and the coming Ketamine revolution

The author is a PhD neuroscientist with a deep understanding of the science and the issues. Instead of rehashing the same oversimplified messages like most articles about ketamine, this one gives a complete explanation of the key issues, and makes them very easy to understand without dumbing anything down. Most articles about ketamine recycle the same soundbites, using the same oversimplified headlines. But this article gives a complete overview, and explains how ketamine fits into the bigger picture of the US mental health care system. It contrasts ketamine against the established approach toward treating depression, which has essentially failed those with severe, treatment-resistant depression. Highly recommended reading.

The author, Dr. Pascal Wallisch, has a blog ( and twitter feed ( that cover topics in neuroscience and psychology. Many of his posts are very relevant to depression sufferers.

8 responses to An outstanding article on ketamine

  1. I try spread the word about ketamine antidepressive properties in Canada, but I myself never yet even had a treatment with positive effects. I still will do because it is my hope. But please everyone who knows the benefits of the new treatment, talk, write, prove to the right people and simply speed up the the process, as many suffering need a life back.

  2. I have been receiving IV Ketamine Treatments for depression from Dr. John Claude Krusz, MD in Dallas Texas for the last 5 months and have had very positive results. Over the last 25 years I have tried all of the antidepressants and ECT with very little positive results but the IV Ketamine Treatments are working very well for me. I would encourage anyone with treatment resistant depression to try IV Ketamine Treatments.

    • Cammie, although I find it impossible to believe, you are the first person I have found to report, not only on having had ketamine treatments, BUT on finding such positive results. I am old, a retired attorney, and have had enough experience with depression to fill a large book. But it is my daughter with whom I am concerned. She is now 40 (unbelievably) and began depression at about 10 or 11. Her history is like that of any long term sufferer of depression – including a year and a half in a pyschiatric hospital. She indeed has lost her life to this illness. I of course saw Dr. Krusz’s name on the Ketamine Advocacy Network website but, for some reason I no longer recall, the info I found about Dr. Diana Ghelber, in Ft. Worth, seemed to make her the preferable doctor in the Dallas – Ft. Worth area. Did you check on her? How did you decide on Dr. Krusz? How did you find him? I would truly appreciate any info you can provide about your experiece (number, duration and frequency of first treatments; when they were reduced (I assume they have been); time required,frequency, ect. at present; cost. As I said, I will be most grateful for any info you may provide. Neilson Jacobs

      • Dear Neilson,

        I too am an attorney, not retired, who has had severe depression. I’m interested in try ketamine, however I live in NY State. I am hoping that when you get this note, you have been able to get your daughter started on this treatment. Let me know how things are going for her and you. Sincerely, Susan

    • Cammie, I tried to send an email to the address shown on yours but got an answer that mine could not be delivered because there was no account on Yahoo. What could be the problem? Can you post one on this website in answer to mine?

  3. I would be interested in hearing any stories about persuading your current physician to implement IV ketamine treatment. My present psych doctor knows all the literature, spend years as an anesthesiologist and, in theory, thinks it’s a wonderful idea. But when it comes comes to convincing him to try it, he balks, saying that the “paperwork would be too much” and it would require “research protocol approval” from the FDA. Any truth to this? I don’t feel like challenging this directly because I’m already viewed as confrontational enough but it’s hard for me to believe. Let’s put up some success stories!

  4. Hello John G,
    I am an anesthesiologist and have been treating patients using ketamine at my clinic for almost 2 years now. Ketamine is not listed as a schedule 1 substance so there is no research paperwork that needs to be completed. Ketamine is schedule 3. As long as the patient is diagnosed accurately by an independent mental health care professional and you have a valid DEA license you are absolutely allowed to prescribe and administer ketamine in a monitored setting. I would be happy to discuss this with you physician if he is still interested in helping out folks like you. This is a complete game changer in many of my patients. They get their lives back. It’s the most rewarding thing I have EVER done in medicine. Regards, Dr. E. Abreu

    • Dr. Abreu,
      Thank you for your response. I can tell you that after many months of deliberative and thoughtful conversation and the sharing of research my psychiatrist is now finally prescribing intranasal ketamine. I agree it is a complete game changer and I think for him there came a tipping point last December where the evidence was just too overwhelming to ignore any longer. His concerns remains the safety profile regarding long-term use (though the amount is modest.) I have had excellent results with intranasal delivery although it has taken some experimentation as to the best amounts and frequencies. I was one of the original guinea pigs at NIH with the ketamine infusion trials and I am so thankful I was accepted and had a positive response. I can completely understand your comment that “It’s the most rewarding thing I have EVER done in medicine.” For me, it is the most successful treatment I have ever experienced.
      Best wishes

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