Research Database

To understand how ketamine works, some will want to read the original scholarly research. We have assembled a database of hundreds of published studies for your reference. To get the most out of it, there are a few things you need to know. See below for a quick intro.

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Just take me to the database.

Using the Database

To open a study, click anywhere on a row. Use the search box to narrow the list of studies based on your interests. The results will be filtered and highlighted instantly as you type. Click on the column headings to sort.

The database contains more than just ketamine studies. If you read every single study on ketamine (we have!) you would be quickly drawn into several overlapping subjects that are essential to understanding the underlying mechanisms.  We’ve included many studies in these related areas for those who wish to dig deep.  Topics include:  NMDA antagonism, glutamate, mTOR signaling, brain-derived neurotrophic factor (BDNF), inlammatory cytokines, childhood maltreatment, HPA axis, hippocampal volume, AMPA receptors, scopolamine, and many more.

Most of the items in our database link directly to PubMed. PubMed is run by the US National Library of Medicine, and catalogs virtually all serious medical research worldwide. It aggregates over 5600 biomedical journals from around the world.

PubMed usually contains an abstract of each publication, plus a link to the journal that originally published it. For many readers, the abstract is enough. If you want the original source material, click the link (usually in the upper right corner of the PubMed page) to go to the full-text article, which will be thick with medical terms and statistics.

Unfortunately, these journals nearly always charge a fee to the general public for full-text articles, usually around $30, so we can’t post them on this site. But there are several ways you might be able to access them for free, by taking advantage of institutional access. Some examples:

  • Many colleges and universities provide their their students and employees with logons that include full-text access.
  • Likewise for many healthcare networks, certain consulting or law firms, pharmaceutical companies, and other large organizations.
  • Check with your employer to see if they have institutional access. You might be surprised.
  • The NIH campus in Bethesda, MD, is open to the public. Anyone who visits can attach to the campus wifi network and get full-text versions of all PubMed articles. There is guest wifi and lots of visitor seating in the Clinical Center (the hospital where the ketamine research is actually conducted). Or you can visit the National Library of Medicine, also on campus. If you are currently participating in an NIH study, you might want to take advantage of this access before you leave.
  • If you can’t get institutional access on your own, check with friends and family members who might have it through their employers.

95% of the database is scholarly research, which means peer-reviewed, controlled, double-blind studies. But there are also a handful of other useful items such as letters to the editor and opinion pieces authored by ketamine researchers.

Don’t use something you read in a single study to make sweeping changes in your current treatment, or to confront your doctor. Look further to see if that finding has been replicated and confirmed in multiple studies. Be smart about whether the item is a recent discovery still being investigated, or a well-established fact with lots of data to confirm it. When you are suffering, it’s tempting to seize on a single finding as “The Answer”, but it’s important to view it in context within the entire body of research.

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